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An FNAB report as suspect follicular nodule refers a patient to surgery, but many patients in this case will have benign diseases on paraffin preparations. A rational presurgical evaluation of these nodules would prevent surgical risk, lifetime hormone reposition and hospital cost. In this histological study galectin-3 was specifically expressed by malignant neoplasm, showing that this molecule could be used as an adequate marker for malignant follicular cells.
Our data corroborate previous works 4, 8, 10, 18, 25, 32 that found consistent expression of galectin-3 by papillary carcinomas, some negative results for follicular carcinomas, and erratic expression by adenomas. High percentages for sensitivity, specificity and predictive values, obtained by our study suggest that galectin-3 expression by a follicular cell may be used as marker for its malignancy. Adenomas expressing galectin-3, as described above, have been classified by previous works as carcinomas without morphological evidence of capsular and vascular invasion 4, 7, 8, Thus, a new possibility of detecting early thyroid cancer can be accomplished with galectin-3 immunostaining test.
However more investigation is certainly needed to certify if this finding is a true or a false positive result. Cytoplasmic galectin-3 expression was found only in carcinomas, and therefore it may be considered an evidence of malignancy. Nuclear staining was not consistently associated with malignant neoplasm and should not be a marker for cancer, until more data are available. Cytoplasmic predominance expression of galectin-3 has been related to progression of normal tissue to adenoma and carcinoma in the colon carcinoma model Our data and previous studies suggest that the same pattern of cellular staining can be used with thyroid neoplasm.
Galectin-3 may play an important role in malignant transformation, especially in cell adherence and metastasis. Several works have associated this molecule with metastasis capability 26, 27 and malignant transformation 30, Our work supports previous findings that this immunodiagnostic method is a simple, cheap and important diagnostic support in distinguishing malignant and benign thyroid neoplasm.
Before application of this method on cytological samples, histological data should be gathered for knowledge of diagnosis statistics. The immunocytochemical method is preferred to other molecular biology-based methods. Because of constitutional stromal expression of galectin-3, methods like immunoblotting show false-positive results Morphological evaluation associated with immunocytostaining with galectin-3 should be the best approach for presurgical evaluation for thyroid nodules.
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We thank Dr. We are also indebted to Dr. Maria Teresa de Godoy Morais for valuable supporting. Cancer Res , v. Fine-needle aspiration of thyroid: an institutional experience. Thyroid , v. Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions. Lancet , v. Improving accuracy of cytology for nodular thyroid lesions. Diagnostic pitfalls in thyroid fine-needle aspiration: a review of cases. Diagn Cytopathol , v.
Distinction between papillary thyroid hyperplasia and papillary thyroid carcinoma by immunohistochemical staining for cytokeratin 19, galectin-3, and HBME Endocr Pathol , v. COLI, A. Galectin-3, a marker of well-differentiated thyroid carcinoma, is expressed in thyroid nodules with cytological atypia. Histopathology , v.
Immunohistochemical localization of galectin-3 in malignant and benign human thyroid tissue.
Thyroid Neoplasms, Volume 4 - 1st Edition
Anticancer Res , v. Expression of galectin-3 in normal and malignant thyroid tissue by quantitative PCR and immunohistochemistry.
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Mod Pathol, v. Galectin-3 and laminin expression in neoplastic and non-neoplastic thyroid tissue. J Pathol, v. Follicular carcinoma. Semin Diag Pathol, v. Biochemistry , v. Fine needle aspiration biopsy of the thyroid: an appraisal.
Ann Intern Med , v. HALL, T. Sources of diagnostic error in fine needle aspiration of the thyroid. Full Name Comment goes here. Are you sure you want to Yes No. Mattie Robertson Suffer from Kidney Disease? Aussie Naturopath tells all Rakhi Sangwan. Chinmay Prajapati. Deepak Pareek , Doctor. Shivaleelapatil Patil. Show More. No Downloads. Views Total views. Actions Shares. Embeds 0 No embeds. No notes for slide. Thyroid neoplasms 1. Classification of Thyroid Neoplasms Benign i Follicular adenoma.
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Children a Follicular thyroid carcinoma b Anaplastic carcinoma c Sporadic Medullary thyroid carcinoma Elderly Orphan annie is strip cartoon character with empty circled eyes It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search. Article Navigation. Close mobile search navigation Article Navigation.
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Thyroid Neoplasms After Radiation Therapy for Adolescent Acne Vulgaris
Abstract A retrospective study of medical records from twelve veterinary university hospitals-clinics yielded dogs with a confirmed diagnosis of a thyroid neoplasm 25 adenomas and carcinomas. Issue Section:. You do not currently have access to this article.